Plenhyage XL® Thin is a regenerative injectable treatment based on highly purified polynucleotides (PDRN), developed to improve skin quality, texture, and elasticity while supporting natural tissue repair. This biostimulatory formulation works at a cellular level to stimulate collagen production and provide deep hydration, helping restore healthier and smoother skin.

Designed for early signs of aging and preventive skin rejuvenation protocols, the treatment delivers gentle yet effective regeneration with natural-looking results. It is particularly suitable for thin or delicate skin areas, including zones requiring careful and precise revitalization.

Product Information:

• Brand: Plenhyage XL®

• Manufacturer: BioFormula

• Category: Polynucleotides · Skin Rejuvenation · Eye Area Treatments

• Country of Origin: Italy

• Import: European Community (EC)

• Certification: CE-marked Medical Device

Plenhyage XL® Thin provides targeted regeneration and hydration for delicate skin, helping achieve smoother, healthier, and naturally rejuvenated skin.

Key ingredients:

• Polynucleotides (PDRN)

Plenhyage XL® Strong 2 ml is an advanced polynucleotide-based injectable developed for intensive skin regeneration and deep tissue repair. Featuring a higher concentration of polynucleotides, this formulation is ideal for restoring firmness and improving skin quality in cases of advanced aging or significant tissue damage.

The treatment stimulates fibroblast activity and collagen production, helping improve skin elasticity, hydration, and texture while providing structural support to weakened tissues. It is particularly effective for addressing deep wrinkles, sagging skin, and pronounced signs of aging, delivering comprehensive skin renewal and rejuvenation.

Derived from purified salmon DNA, the formulation ensures excellent biocompatibility with minimal risk of immune reactions. Fully absorbable, the treatment offers a safe and natural regenerative solution with visible and long-lasting improvements.

Product Information:

• Brand: Plenhyage XL®

• Manufacturer: BioFormula

• Category: Polynucleotides · Skin Rejuvenation · Body Treatments

• Country of Origin: Italy

• Import: European Community (EC)

• Certification: CE-marked Medical Device

Plenhyage XL® Strong provides deep regenerative support and firming action, helping restore smoother, stronger, and more youthful-looking skin across face and body areas.

Key ingredients:

• Polynucleotides 25mg/ml
• Hyaluronic acid

Plenhyage XL® Medium 2 ml is a polynucleotide-based injectable treatment developed to support skin regeneration and tissue repair, improving hydration, elasticity, and overall skin quality. Formulated with highly purified polymerized polynucleotides (PDRN), the treatment stimulates cellular renewal processes and strengthens skin structure.

By activating fibroblasts and promoting collagen production, the treatment helps improve skin texture, reduce fine lines, and support recovery from scarring, UV damage, and visible signs of aging. Derived from purified salmon DNA, the formulation offers excellent biocompatibility with minimal risk of immune reaction.

In addition to its regenerative properties, the treatment also provides antioxidant protection against free radicals, contributing to long-lasting skin rejuvenation and improved tissue resilience.

Product Information:

• Brand: Plenhyage XL®

• Manufacturer: BioFormula

• Category: Polynucleotides · Skin Rejuvenation

• Country of Origin: Italy

• Import: European Community (EC)

• Certification: CE-marked Medical Device

Plenhyage XL® Medium delivers regenerative skin support and revitalization, helping restore smoother, healthier, and more elastic skin through collagen stimulation and deep tissue repair.

Key ingredients:

• Polynucleotides 20mg/ml
• Hyaluronic acid

Plinest® One 4 ml is a next-generation injectable treatment developed to improve skin quality across larger body areas, delivering deep hydration, enhanced firmness, and improved elasticity. Based on polynucleotides derived from purified salmon DNA, the formulation stimulates fibroblast activity, promoting collagen and elastin production while reinforcing the extracellular matrix (ECM) for long-lasting tissue rejuvenation.

The treatment is particularly suitable for areas such as the arms, legs, abdomen, and other body zones, helping address skin laxity and stretch marks, and is especially effective in younger patients experiencing early skin relaxation.

Compared to standard 2 ml treatments, Plinest® One offers double the volume (4 ml per vial), providing a more efficient and cost-effective solution for treating larger areas while maintaining the same high-quality regenerative formulation.

Results generally last 6 to 12 months, depending on individual skin condition and lifestyle factors, with maintenance sessions helping prolong improvements.

Product Information:

• Brand: Plinest®

• Manufacturer: Mastelli

• Category: Polynucleotides · Skin Rejuvenation

• Country of Origin: Italy

• Import: European Community (EC)

• Certification: CE-marked Medical Device

Plinest® One provides effective regeneration and tightening for larger treatment zones, helping achieve smoother, firmer, and healthier-looking skin across the body.

The pack consists of:

• 5 vials x 4ml

Key ingredients: 

• 2 mg/ml of polynucleotides

Plinest® Hair 2 ml by Mastelli is an advanced injectable treatment based on polynucleotides, specifically formulated to improve scalp health and enhance hair quality. The treatment is also recommended for trophic support of eyebrows and beard areas, helping strengthen and revitalize hair growth zones.

Derived from purified salmon DNA, the polynucleotides help regenerate hair follicles and stimulate fibroblast activity at a cellular level. This process improves scalp elasticity, enhances hydration, boosts microcirculation, and promotes collagen production, creating healthier conditions for hair growth.

Suitable for both men and women, the treatment is ideal for individuals experiencing early stages of hair thinning or hair loss, supporting scalp regeneration and improving hair quality. Results generally last 6 to 12 months, depending on factors such as hair type, degree of hair loss, and overall health condition. Maintenance treatments can help prolong results and support continuous scalp and hair revitalization.

Product Information:

• Brand: Plinest®

• Manufacturer: Mastelli

• Category: Polynucleotides · Skin Rejuvenation · Hair Treatments

• Country of Origin: Italy

• Import: European Community (EC)

• Certification: CE-marked Medical Device

Plinest® Hair delivers targeted scalp revitalization and follicular support, helping achieve stronger, healthier-looking hair and improved scalp condition over time.

The pack consists of:

• 1 x 2ml prefilled syringe
• 2 x 30G ½ needles

Key ingredients: 

• 15 mg of polynucleotides (7,5mg/ml)

Plinest® Eye 2 ml is a specialized injectable treatment developed for the delicate eye contour area, addressing concerns such as fine lines, superficial wrinkles, crow’s feet, dark circles, and skin laxity around the eyes. The treatment improves skin quality while restoring a fresher and more youthful appearance.

This polynucleotide-based gel, derived from purified salmon DNA, works at a cellular level by stimulating tissue regeneration, improving microcirculation, and enhancing collagen production. The result is improved skin elasticity and hydration, helping smooth the under-eye area and reduce visible signs of fatigue and aging.

Results typically last 6 to 12 months, depending on individual skin characteristics, age, and lifestyle. Periodic maintenance treatments can help prolong and optimize rejuvenation outcomes.

Product Information:

• Brand: Plinest®

• Manufacturer: Mastelli

• Category: Polynucleotides · Skin Rejuvenation · Eye Area Treatments

• Country of Origin: Italy

• Import: European Community (EC)

• Certification: CE-marked Medical Device

Plinest® Eye provides targeted regeneration and hydration for the eye area, helping achieve smoother, brighter, and rejuvenated skin around the eyes.

The pack consists of:

• 1 x 2ml prefilled syringe
• 2 x 30G ½ needles

Key ingredients: 

• 15 mg of polynucleotides (7,5mg/ml)